Researchers Engineer Custom Calcium Channels Through Computational Protein Design
A breakthrough in protein design enables creation of custom calcium channels from scratch. The approach uses generative AI to build channels around precisely defined selectivity filters, achieving calcium selectivity that eluded previous methods.
Breakthrough in Custom Ion Channel Engineering
Researchers have reportedly developed a novel computational approach to design custom calcium-selective ion channels from scratch, according to a recent Nature publication. The method represents a significant advancement in de novo protein design, enabling scientists to construct ion channels with precisely specified selectivity filters that determine which ions can pass through.