Landmark Study Maps Genetic Resistance in Blood Cancer Treatment Using Advanced Gene Editing
Scientists have developed the most complete map yet of genetic mutations that cause treatment resistance in chronic myeloid leukemia. The breakthrough study used advanced gene editing to test nearly all possible mutations against five generations of targeted therapies.
Breakthrough in Understanding Cancer Drug Resistance
Researchers have created the most comprehensive map to date of genetic mutations that cause resistance to chronic myeloid leukemia (CML) treatments, according to a recent study published in Nature Biomedical Engineering. The research team used prime editing, an advanced gene-editing technology, to systematically test how nearly all possible mutations in the ABL1 gene affect response to five different tyrosine kinase inhibitors (TKIs).
