Researchers have developed a novel targeted glue technology that selectively degrades the BRD9 protein. This approach represents a third generation of protein degradation therapeutics beyond PROTACs. The discovery could unlock treatments for cancers and other diseases involving previously undruggabl
A breakthrough in protein design enables creation of custom calcium channels from scratch. The approach uses generative AI to build channels around precisely defined selectivity filters, achieving calcium selectivity that eluded previous methods.
Researchers have reportedly developed a novel computational approach to design custom calcium-selective ion channels from scratch, according to a recent Nature publication. The method represents a significant advancement in de novo protein design, enabling scientists to construct ion channels with precisely specified selectivity filters that determine which ions can pass through.
Revolutionizing GPCR Therapeutics with Targeted Allosteric Modulation G protein-coupled receptors (GPCRs) represent one of the most important drug targets in…
Researchers report promising early results with a novel cardiac gene therapy targeting advanced heart failure patients. The approach uses an engineered viral vector to deliver a key regulatory protein, potentially overcoming limitations that hampered previous attempts in the field.
After more than a decade of clinical setbacks, gene therapy for heart failure is showing renewed promise according to recent research published in Nature Medicine. Sources indicate that a novel approach using an engineered viral vector to deliver a therapeutic protein has demonstrated potential in early human trials, marking what analysts suggest could be a turning point for molecular interventions targeting the failing heart.
