A comprehensive French study analyzing over 2,700 stem cell transplant patients has identified significant risk factors for graft failure. Researchers found that HLA mismatching and donor-specific antibodies substantially increase transplantation complications, with important implications for patient survival and retransplantation strategies.
Major Study Identifies Critical Risk Factors in Stem Cell Transplantation
New research published in Bone Marrow Transplantation has revealed crucial insights into the factors contributing to graft failure following unrelated donor hematopoietic stem cell transplantation. The comprehensive study, conducted by the French Society for Stem Cell Transplantation (SFGM-TC) and French Histocompatibility and Immunogenetics Study Group (SFHI), analyzed data from 2,716 patients who underwent transplantation between 2006 and 2012.