SIRT5 Enzyme Discovery Reveals New Pathway in Breast Cancer Treatment Resistance
A groundbreaking study reveals how protein modification through succinylation affects cancer cell response to chemotherapy. The research identifies SIRT5 as a key regulator of MTHFD2 activity, influencing NADPH production and cellular senescence pathways in breast cancer treatment resistance.
Breakthrough in Understanding Cancer Treatment Resistance
Scientists have uncovered a previously unknown mechanism that enables breast cancer cells to develop resistance to chemotherapy, according to recent research published in Communications Biology. The study reveals how specific protein modifications, particularly lysine succinylation, play a crucial role in how cancer cells evade treatment-induced cellular senescence and continue proliferating.