Tag: Dalton (unit)

InnovationScienceTechnology

Scientists Discover Nitrogenase-Like Enzyme That Breaks Down Sulfur Compounds

A groundbreaking study has uncovered how certain enzymes use nitrogenase-like machinery to break down sulfur-containing compounds. The findings could reshape our understanding of enzyme evolution and industrial applications.

Nitrogenase-Inspired Enzyme Reveals New Catalytic Capabilities

Scientists have made a significant breakthrough in understanding how certain enzymes break down sulfur-containing compounds using nitrogenase-like metalloclusters, according to research published in Nature Catalysis. The study reveals that methylthio-alkane reductases, enzymes that cleave carbon-sulfur bonds, employ complex iron-sulfur clusters similar to those found in nitrogen-fixing enzymes but with crucial structural differences that enable their unique function.

by Desai Priyanka
ResearchScienceTechnology

Breakthrough Cryo-EM Strategy Enables High-Resolution Imaging of Small Cancer Proteins

Scientists have overcome a major limitation in cryo-electron microscopy by developing a novel fusion strategy that enables high-resolution structural determination of small proteins. The breakthrough method successfully resolved the structure of cancer-related kRasG12C at 3.7 Å resolution, clearly showing how inhibitor drug MRTX849 interacts with its target.

Overcoming Size Limitations in Structural Biology

Structural biologists have reportedly developed an innovative approach that extends the capabilities of cryo-electron microscopy to small protein targets previously considered too challenging for high-resolution analysis, according to recent research published in Scientific Reports. The new method addresses what sources indicate has been a fundamental limitation in the field—the difficulty of imaging proteins smaller than 50 kilodaltons (kDa) using single-particle cryo-EM techniques.

by Desai Priyanka