InnovationResearchScience

Scientists Design First Liquid Relaxor Ferroelectrics Through Molecular Engineering

Researchers have conceived a new class of liquid relaxor ferroelectrics by strategically introducing polarity heterogeneity. The breakthrough enables enhanced dielectric responses previously unattainable in liquid matter systems.

Revolutionary Approach to Liquid Ferroelectrics

Scientists have reportedly designed the first liquid-matter relaxor ferroelectrics (nRFE) through direct molecular engineering, according to research published in Nature Communications. Unlike conventional solid-state relaxor ferroelectrics that rely on chemical doping in crystalline lattices, this novel approach introduces polarity heterogeneity by dispersing polar nanoregions (nPNRs) within apolar nematic liquid crystal backgrounds. Sources indicate this represents a paradigm shift in ferroelectric material design, enabling unprecedented dielectric properties in fluid systems.

BiotechnologyHealthcareResearch

Landmark Study Maps Genetic Resistance in Blood Cancer Treatment Using Advanced Gene Editing

Scientists have developed the most complete map yet of genetic mutations that cause treatment resistance in chronic myeloid leukemia. The breakthrough study used advanced gene editing to test nearly all possible mutations against five generations of targeted therapies.

Breakthrough in Understanding Cancer Drug Resistance

Researchers have created the most comprehensive map to date of genetic mutations that cause resistance to chronic myeloid leukemia (CML) treatments, according to a recent study published in Nature Biomedical Engineering. The research team used prime editing, an advanced gene-editing technology, to systematically test how nearly all possible mutations in the ABL1 gene affect response to five different tyrosine kinase inhibitors (TKIs).

ResearchScienceTechnology

Breakthrough Cryo-EM Strategy Enables High-Resolution Imaging of Small Cancer Proteins

Scientists have overcome a major limitation in cryo-electron microscopy by developing a novel fusion strategy that enables high-resolution structural determination of small proteins. The breakthrough method successfully resolved the structure of cancer-related kRasG12C at 3.7 Å resolution, clearly showing how inhibitor drug MRTX849 interacts with its target.

Overcoming Size Limitations in Structural Biology

Structural biologists have reportedly developed an innovative approach that extends the capabilities of cryo-electron microscopy to small protein targets previously considered too challenging for high-resolution analysis, according to recent research published in Scientific Reports. The new method addresses what sources indicate has been a fundamental limitation in the field—the difficulty of imaging proteins smaller than 50 kilodaltons (kDa) using single-particle cryo-EM techniques.